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Trends Biochem Sci. 2014 Nov;39(11):517-26. doi: 10.1016/j.tibs.2014.08.009. Epub 2014 Oct 1.

Botulinum neurotoxins: new questions arising from structural biology.

Author information

1
Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland. Electronic address: richard.kammerer@psi.ch.
2
Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.

Abstract

Botulinum neurotoxins (BoNTs) are the most toxic substances known and cause botulism in vertebrates. They have also emerged as effective and powerful reagents for cosmetic and medical applications. One important prerequisite for understanding BoNT function in disease, and the further development of the toxins for cosmetic and medical applications, is a detailed knowledge of BoNT interactions with non-toxic neurotoxin-associated proteins and cell surface receptors. Based on the substantial recent progress in obtaining high-resolution crystal structures of key BoNT complexes, we summarize the major advances in understanding BoNT interactions and discuss the resulting potential implications, in particular those relating to BoNT serotype A.

KEYWORDS:

Botulinum neurotoxin; X-ray crystallography; cell surface receptors; progenitor-toxin complex; subtype

PMID:
25282537
DOI:
10.1016/j.tibs.2014.08.009
[Indexed for MEDLINE]
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