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FEBS Lett. 2014 Dec 20;588(24):4527-35. doi: 10.1016/j.febslet.2014.09.035. Epub 2014 Oct 2.

MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9.

Author information

1
Analytical & Testing Center, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
2
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
3
Analytical & Testing Center, Nanjing Medical University, Nanjing, Jiangsu 210029, China. Electronic address: wangfuqiang0802@163.com.

Abstract

It has been demonstrated that miR-874 plays important roles in many types of cancers. Nevertheless, its biological function in breast cancer remains largely unknown. In this study, we found that the expression level of miR-874 is down-regulated in breast cancer in comparison with the adjacent normal tissues. The overexpression of miR-874 is able to inhibit cell proliferation and induce cell apoptosis and cell cycle arrest in MCF7 and MDA-MB-231 cells. Using a bioinformatics method, we further show that CDK9 is a direct target of miR-874 and that its protein level is negatively regulated by miR-874. Therefore, the data reported in this manuscript demonstrate that miR-874 is an important regulator in breast cancer and imply that the miR-874/CDK9 axis has potential as a therapeutic target for breast cancer.

KEYWORDS:

Apoptosis; Breast cancer; CDK9; Cell cycle; Cell proliferation; miR-874

PMID:
25281924
DOI:
10.1016/j.febslet.2014.09.035
[Indexed for MEDLINE]
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