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J Biol Chem. 2014 Nov 7;289(45):30880-8. doi: 10.1074/jbc.R114.609248. Epub 2014 Oct 3.

Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter.

Author information

1
From the Department of Pathology and Molecular Medicine and Division of Cancer Biology and Genetics, Queen's University, Kingston, Ontario K7L 3N6, Canada spc.cole@queensu.ca.

Abstract

The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a broader role than simply mediating the ATP-dependent efflux of drugs from cells. The antioxidant GSH and the pro-inflammatory cysteinyl leukotriene C4 have been identified as key physiological organic anions effluxed by MRP1, and an ever growing body of evidence indicates that additional lipid-derived mediators are also substrates of this transporter. As such, MRP1 is a multitasking transporter that likely influences the etiology and progression of a host of human diseases.

KEYWORDS:

ABC Transporter; Inflammation; Leukotriene; Lipid Signaling; Lipid Transport; Lysophospholipid; MRP1; Multidrug Transporter; Organic Anion Transport; Oxidative Stress

PMID:
25281745
PMCID:
PMC4223294
DOI:
10.1074/jbc.R114.609248
[Indexed for MEDLINE]
Free PMC Article

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