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Talanta. 2015 Jan;131:661-5. doi: 10.1016/j.talanta.2014.08.042. Epub 2014 Aug 26.

Characterization of Fe3O4/SiO2/Gd2O(CO3)2 core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent.

Author information

1
Chemistry Department, East China Normal University, Shanghai 200241, PR China; Antibiotics Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, PR China.
2
Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai 200241, PR China.
3
Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai 200241, PR China. Electronic address: chunhua_luo@hotmail.com.
4
Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai 200241, PR China; Polymer Electronic Research Centre, The University of Auckland, Private Bag 92019, Auckland, New Zealand; State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, PR China. Electronic address: h.peng@auckland.ac.nz.
5
Chemistry Department, East China Normal University, Shanghai 200241, PR China.

Abstract

Core/shell/shell structured Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles were successfully synthesized. Their properties as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging were investigated. Due to the introduce of a separating SiO2 layer, the magnetic coupling between Gd2O(CO3)2 and Fe3O4 could be modulated by the thickness of SiO2 layer and produce appropriate T1 and T2 signal. Additionally, the existence of Gd(3+) enhances the transverse relaxivity of Fe3O4 possibly because of the magnetic coupling between Gd(3+) and Fe3O4. The Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles exhibit good biocompatibility, showing great potential for biomedical applications.

KEYWORDS:

Contrast agents; Fe(3)O(4)/SiO(2)/Gd(2)O(CO(3))(2); Magnetic resonance imaging; Nanoparticles

PMID:
25281156
DOI:
10.1016/j.talanta.2014.08.042
[Indexed for MEDLINE]

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