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World J Gastroenterol. 2014 Sep 28;20(36):12993-3005. doi: 10.3748/wjg.v20.i36.12993.

Endoscopic features of gastro-intestinal lymphomas: from diagnosis to follow-up.

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Calogero Vetro, Alessandra Romano, Irene Amico, Concetta Conticello, Giovanna Motta, Amalia Figuera, Annalisa Chiarenza, Cosimo Di Raimondo, Giuseppe Alberto Palumbo, Francesco Di Raimondo, Division of Hematology, AOU Policlinico-OVE, University of Catania, 95124 Catania, Italy.


Many progresses have been done in the management of gastrointestinal (GI) lymphomas during last decades, especially after the discovery of Helicobacter pylori-dependent lymphoma development. The stepwise implementation of new endoscopic techniques, by means of echoendoscopy or double-balloon enteroscopy, enabled us to more precisely describe the endoscopic features of GI lymphomas with substantial contribution in patient management and in tailoring the treatment strategy with organ preserving approaches. In this review, we describe the recent progresses in GI lymphoma management from disease diagnosis to follow-up with a specific focus on the endoscopic presentation according to the involved site and the lymphoma subtype. Additionally, new or emerging endoscopic technologies that have an impact on the management of gastrointestinal lymphomas are reported. We here discuss the two most common subtypes of GI lymphomas: the mucosa-associated lymphoid tissue and the diffuse large B cell lymphoma. A general outline on the state-of-the-art of the disease and on the role of endoscopy in both diagnosis and follow-up will be performed.


B-cell lymphomas; Endoscopy; Endosonography; Gastrointestinal tract; Marginal zone; Non-Hodgkin lymphomas

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