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World J Gastroenterol. 2014 Sep 28;20(36):12934-44. doi: 10.3748/wjg.v20.i36.12934.

Alcoholic liver disease: treatment.

Author information

1
Ki Tae Suk, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.

Abstract

The excess consumption of alcohol is associated with alcoholic liver diseases (ALD). ALD is a major healthcare problem, personal and social burden, and significant reason for economic loss worldwide. The ALD spectrum includes alcoholic fatty liver, alcoholic hepatitis, cirrhosis, and the development of hepatocellular carcinoma. The diagnosis of ALD is based on a combination of clinical features, including a history of significant alcohol intake, evidence of liver disease, and laboratory findings. Abstinence is the most important treatment for ALD and the treatment plan varies according to the stage of the disease. Various treatments including abstinence, nutritional therapy, pharmacological therapy, psychotherapy, and surgery are currently available. For severe alcoholic hepatitis, corticosteroid or pentoxifylline are recommended based on the guidelines. In addition, new therapeutic targets are being under investigation.

KEYWORDS:

Alcoholic; Liver disease; Treatment

PMID:
25278689
PMCID:
PMC4177474
DOI:
10.3748/wjg.v20.i36.12934
[Indexed for MEDLINE]
Free PMC Article

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