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J Periodontol. 2015 Jan;86(1):27-35. doi: 10.1902/jop.2014.140138.

Effects of an ascorbic acid-derivative dentifrice in patients with gingivitis: a double-masked, randomized, controlled clinical trial.

Author information

1
Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan.

Abstract

BACKGROUND:

Reactive oxygen species might be associated with the onset and progression of gingival inflammation. The aim of this study is to investigate the effect of a dentifrice containing L-ascorbic acid 2-phosphate magnesium salt (APM), a long-acting ascorbic acid derivative with antioxidant properties, on gingival inflammation.

METHODS:

The clinical effects of APM were investigated in a multicenter, randomized, parallel-group, controlled clinical trial comprising 300 individuals with gingivitis. Half of the participants were given an APM-containing dentifrice and half were given a control dentifrice. The primary outcome was the gingival index (GI) at 3 months. Secondary outcomes included gingival redness as an indicator of the degree of local gingival inflammation, gingival bleeding as a measure of the gingivitis severity index, and total antioxidant activity of the saliva.

RESULTS:

Under the intent-to-treat analysis, GI did not significantly differ between the groups (P = 0.12). However, under the per-protocol analysis, GI was significantly lower in the APM group (P = 0.01) than in the control group. In the APM group, gingival redness was significantly lower, and the difference from the baseline gingivitis severity index was significantly greater (P = 0.04 and P = 0.02, respectively). The total antioxidant activity of the saliva was significantly higher in the APM group (P = 0.03). The incidence of adverse events did not significantly differ between the groups (P > 0.15).

CONCLUSION:

These findings indicate that the regular application of an APM-containing dentifrice could reduce gingival inflammation.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT02102295.

KEYWORDS:

Antioxidants; controlled clinical trials; dentifrices, ascorbic acid; gingivitis; randomized; reactive oxygen species; saliva

PMID:
25277459
DOI:
10.1902/jop.2014.140138
[Indexed for MEDLINE]

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