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EMBO J. 1989 May;8(5):1341-8.

Endocytosis and recycling of the fibronectin receptor in CHO cells.

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Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.

Erratum in

  • EMBO J 1989 Jul;8(7):2122.


An anti-fibronectin receptor monoclonal antibody preferentially labels the leading edges of freshly plated CHO fibroblasts, suggesting that this receptor circulates through the endocytic cycle. Using a new labelling reagent, I show that this receptor is indeed endocytosed at 37 degrees C and then returned to the cell surface. These findings imply that fibronectin receptors are recirculated to the leading edge of a motile cell by the endocytic cycle, and establish that the processes of endocytosis/exocytosis and cell locomotion are intimately linked.

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