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Anticancer Res. 2014 Oct;34(10):5689-93.

Short-term outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: preliminary analysis of a multicentre study.

Author information

  • 1Department of Human Pathology, University of Messina, Messina, Italy amacri@unime.it.
  • 2Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • 3Department of Surgery, University of Genoa, Genoa, Italy.
  • 41st Department of General Surgery, University of Verona, Verona, Italy.
  • 5Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
  • 6Department of Obstetrics & Gynaecology, Catholic University of Sacred Heart, Rome, Italy.
  • 7Department of Human Pathology, University of Messina, Messina, Italy.
  • 8Gynecologic Oncology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy.
  • 9Department of Surgery "Pietro Valdoni", University "Sapienza" of Rome, Rome, Italy.
  • 10Department of Surgery, San Raffaele Scientific Institute, Milan, Italy.
  • 11Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, Bologna, Italy.

Abstract

AIM:

To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy.

PATIENTS AND METHODS:

A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis.

RESULTS:

In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity.

CONCLUSION:

Careful patient selection has to be performed to improve clinical outcomes.

KEYWORDS:

Cytoreductive surgery; HIPEC; hyperthermia; morbidity; mortality

PMID:
25275075
[PubMed - indexed for MEDLINE]
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