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Anticancer Res. 2014 Oct;34(10):5689-93.

Short-term outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: preliminary analysis of a multicentre study.

Author information

  • 1Department of Human Pathology, University of Messina, Messina, Italy
  • 2Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • 3Department of Surgery, University of Genoa, Genoa, Italy.
  • 41st Department of General Surgery, University of Verona, Verona, Italy.
  • 5Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
  • 6Department of Obstetrics & Gynaecology, Catholic University of Sacred Heart, Rome, Italy.
  • 7Department of Human Pathology, University of Messina, Messina, Italy.
  • 8Gynecologic Oncology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy.
  • 9Department of Surgery "Pietro Valdoni", University "Sapienza" of Rome, Rome, Italy.
  • 10Department of Surgery, San Raffaele Scientific Institute, Milan, Italy.
  • 11Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, Bologna, Italy.



To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy.


A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis.


In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity.


Careful patient selection has to be performed to improve clinical outcomes.


Cytoreductive surgery; HIPEC; hyperthermia; morbidity; mortality

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