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Nucleic Acids Res. 2015 Jan;43(Database issue):D578-82. doi: 10.1093/nar/gku903. Epub 2014 Oct 1.

ViRBase: a resource for virus-host ncRNA-associated interactions.

Author information

1
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China.
2
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
3
Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, China State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
4
Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, China.
5
Department of Pathology, Harbin Medical University, Harbin, China.
6
Department of Microbiology, Harbin Medical University, Harbin, China.
7
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China wangdong@ems.hrbmu.edu.cn.

Abstract

Increasing evidence reveals that diverse non-coding RNAs (ncRNAs) play critically important roles in viral infection. Viruses can use diverse ncRNAs to manipulate both cellular and viral gene expression to establish a host environment conducive to the completion of the viral life cycle. Many host cellular ncRNAs can also directly or indirectly influence viral replication and even target virus genomes. ViRBase (http://www.rna-society.org/virbase) aims to provide the scientific community with a resource for efficient browsing and visualization of virus-host ncRNA-associated interactions and interaction networks in viral infection. The current version of ViRBase documents more than 12,000 viral and cellular ncRNA-associated virus-virus, virus-host, host-virus and host-host interactions involving more than 460 non-redundant ncRNAs and 4400 protein-coding genes from between more than 60 viruses and 20 hosts. Users can query, browse and manipulate these virus-host ncRNA-associated interactions. ViRBase will be of help in uncovering the generic organizing principles of cellular virus-host ncRNA-associated interaction networks in viral infection.

PMID:
25274736
PMCID:
PMC4384010
DOI:
10.1093/nar/gku903
[Indexed for MEDLINE]
Free PMC Article

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