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Cold Spring Harb Perspect Biol. 2014 Oct 1;6(10):a016048. doi: 10.1101/cshperspect.a016048.

Missing pieces of an ancient puzzle: evolution of the eukaryotic membrane-trafficking system.

Author information

1
Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
2
Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.

Abstract

The membrane-trafficking system underpins cellular trafficking of material in eukaryotes and its evolution would have been a watershed in eukaryogenesis. Evolutionary cell biological studies have been unraveling the history of proteins responsible for vesicle transport and organelle identity revealing both highly conserved components and lineage-specific innovations. Recently, endomembrane components with a broad, but patchy, distribution have been observed as well, pieces that are missing from our cell biological and evolutionary models of membrane trafficking. These data together allow for new insights into the history and forces that shape the evolution of this critical cell biological system.

PMID:
25274701
PMCID:
PMC4176009
DOI:
10.1101/cshperspect.a016048
[Indexed for MEDLINE]
Free PMC Article

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