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Phytother Res. 2015 Jan;29(1):14-6. doi: 10.1002/ptr.5231. Epub 2014 Oct 2.

A review of the receptor binding and pharmacological effects of N-methyltyramine.

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School of Pharmacy and Health Professions, Creighton University, Omaha, NE, 68178, USA; AdvoCare International, Plano, TX, 75074, USA.


N-methyltyramine (NMT) is a protoalkaloid isolated from various plant species. It is assumed that NMT is an adrenergic agonist with pharmacological properties similar to other structurally related biogenic amines. Current research studies indicate that NMT is an α-adrenoreceptor antagonist, and exhibits modest inhibitory (antagonistic) activity with respect to the breakdown of fats (lipolysis). Furthermore, NMT has been shown to enhance appetite and digestion of foods through its stimulatory effects on gastrin and pancreatic secretions. As a consequence, NMT is not an ingredient that should be used in dietary supplements designed to promote weight loss. It may result in an increase in perceived energy by promoting appetite and the digestion and absorption of nutrients while inhibiting the breakdown to fats to energy.


N-methyltyramine; adrenergic receptors; antagonist; mechanism

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