Format

Send to

Choose Destination
Radiat Environ Biophys. 2015 Mar;54(1):123-136. doi: 10.1007/s00411-014-0568-z. Epub 2014 Oct 2.

Radon balneotherapy and physical activity for osteoporosis prevention: a randomized, placebo-controlled intervention study.

Author information

1
Institute of Physiology and Pathophysiology, Paracelsus Medical University Salzburg, Strubergasse 21, 5020, Salzburg, Austria.
2
Statistical Consulting Unit, Department of Statistics, Ludwig Maximilians Universität München, Akademiestr.1, 80799, München, Germany.
3
, Mühlbachweg 2, 5081, Anif, Austria.
4
Gastein Research Institute, Paracelsus Medical University, Schareckstrasse 4, 5640, Bad Gastein, Austria.
5
Institute of Physiology and Pathophysiology, Paracelsus Medical University Salzburg, Strubergasse 21, 5020, Salzburg, Austria. arnulf.hartl@pmu.ac.at.

Abstract

Low-dose radon hyperthermia balneo treatment (LDRnHBT) is applied as a traditional measure in the non-pharmacological treatment of rheumatic diseases in Europe. During the last decades, the main approach of LDRnHBT was focused on the treatment of musculoskeletal disorders, but scientific evidence for the biological background of LDRnHBT is weak. Recently, evidence emerged that LDRnHBT influences bone metabolism. We investigated, whether combined LDRnHBT and exercise treatment has an impact on bone metabolism and quality of life in a study population in an age group at risk for developing osteoporosis. This randomized, double-blind, placebo-controlled trial comprised guided hiking tours and hyperthermia treatment in either radon thermal water (LDRnHBT) or radon-free thermal water (PlaceboHBT). Markers of bone metabolism, quality of life and somatic complaints were evaluated. Statistics was performed by linear regression and a linear mixed model analysis. Significant changes over time were observed for most analytes investigated as well as an improvement in self-assessed health in both groups. No significant impact from the LDRnHBT could be observed. After 6 months, the LDRnHBT group showed a slightly stronger reduction of the osteoclast stimulating protein receptor activator of nuclear kB-ligand compared to the PlaceboHBT group, indicating a possible trend. A combined hyperthermia balneo and exercise treatment has significant immediate and long-term effects on regulators of bone metabolism as well as somatic complaints. LDRnHBT and placeboHBT yielded statistically equal outcomes.

PMID:
25274266
DOI:
10.1007/s00411-014-0568-z
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center