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Acta Neuropsychiatr. 2015 Feb;27(1):1-7. doi: 10.1017/neu.2014.26. Epub 2014 Oct 2.

The Diagnostic Apathia Scale predicts a dose-remission relationship of T-PEMF in treatment-resistant depression.

Author information

1
1Psychiatric Research Unit,Psychiatric Centre North Zealand,Copenhagen University Hospital,Hillerød,Denmark.
2
2Department of Psychiatry,Psychiatric Centre Copenhagen,Copenhagen University Hospital,Copenhagen,Denmark.
3
3Psychiatric Research Unit,Psychiatric Centre Copenhagen,Copenhagen University Hospital,Copenhagen NV,Denmark.
4
4Department of Cellular and Molecular Medicine,Panum institute,University of Copenhagen,Copenhagen,Denmark.
5
5Department of Affective Disorders,Mood Disorders Research Unit,Aarhus University Hospital,Aarhus,Denmark.

Abstract

OBJECTIVE:

The aim of this study was to evaluate the predictive validity of the apathy subsyndrome in patients with therapy-resistant depression in the dose-remission study with transcranial pulsating electromagnetic fields (T-PEMF).

METHODS:

The apathy subsyndrome consists of the symptoms of fatigue, concentration and memory problems, lack of interests, difficulties in making decisions, and sleep problems. We evaluated 65 patients with therapy-resistant depression. In total, 34 of these patients received placebo T-PEMF in the afternoon and active T-PEMF in the morning, that is, one daily dose. The remaining 31 patients received active T-PEMF twice daily. Duration of treatment was 8 weeks in both groups. The Hamilton Depression Scale (HAM-D17) and the Bech-Rafaelsen Melancholia Scale (MES) were used to measure remission. We also focused on the Diagnostic Apathia Scale, which is based on a mixture of items from the MINI and the HAM-D17/MES.

RESULTS:

In patients without apathy, the remission rate after T-PEMF was 83.9% versus 58.8% in patients with apathy (p≤0.05). In patients without apathy receiving one active dose daily 94.4% remitted versus 50% for patients with apathy (p≤0.05). In patients without apathy who received two active doses 69.9% remitted versus 66.7% for patients with apathy (p≤0.05).

CONCLUSION:

Taking the baseline diagnosis of the apathy syndrome into consideration, we found that in patients without apathy one daily dose of T-PEMF is sufficient, but in patients with apathy two daily doses are necessary. Including the apathy syndrome as predictor in future studies would seem to be clinically relevant.

KEYWORDS:

treatment-resistant depression

PMID:
25273893
DOI:
10.1017/neu.2014.26
[Indexed for MEDLINE]

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