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Int J Med Mushrooms. 2014;16(4):339-44.

Antihypoxic activities of the golden Chanterelle Mushroom, Cantharellus cibarius (higher Basidiomycetes).

Author information

1
Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
2
Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, 48189, Sari, Iran.

Abstract

Cantharellus cibarius is an edible mushroom with worldwide distribution. Because of its good radical scavenging and strong iron-chelating activity, this mushroom was nominated for assay of antihypoxic activity. Protective effects of Chanterelle extract against hypoxia-induced lethality in mice were evaluated by 3 experimental models of hypoxia: asphyctic, hemic, and circulatory. Antihypoxic activity was especially pronounced in the hemic model. The effect was dose dependent. C. cibarius extract (600 mg kg-1) kept the mice alive for 10.07 ± 1.18 min. It significantly (P < 0.0001) and dose dependently prolonged survival time compared to control group (7.00 ± 0.63 min). Extract at 300 mg kg-1 prolonged survival time to 9.94 ± 0.87 min, which was statistically significant (P < 0.0001) compared to control group. In circulatory model, C. cibarius extract (600 mg kg-1) was effective. It prolonged latency for death significantly with regard to the control group (15.18 ± 4.21 vs. 9.84 ± 0.75 min; P < 0.001). At 300 mg kg-1, the extract also prolonged survival time (13.57 ± 0.87 min), and this effect was also statistically significant compared to the control group (P < 0.01). Extract showed no activity in the asphyctic model. Mice in the control group died of hypoxia in 28.20 ± 3.27 min. Extract (600 mg kg-1) prolonged latency for death, but this activity was not statistically significant (P < 0.05). Phenytoin prolonged latency for death to 55.00 ± 6.05 min (P < 0.0001).

PMID:
25271862
[Indexed for MEDLINE]

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