Format

Send to

Choose Destination
Curr Opin Microbiol. 2014 Oct;21:28-34. doi: 10.1016/j.mib.2014.09.003. Epub 2014 Sep 29.

Collective antibiotic resistance: mechanisms and implications.

Author information

1
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.
2
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: gore@mit.edu.

Abstract

In collective resistance, microbial communities are able to survive antibiotic exposures that would be lethal to individual cells. In this review, we explore recent advances in understanding collective resistance in bacteria. The population dynamics of 'cheating' in a system with cooperative antibiotic inactivation have been described, providing insight into the demographic factors that determine resistance allele frequency in bacteria. Extensive work has elucidated mechanisms underlying collective resistance in biofilms and addressed questions about the role of cooperation in these structures. Additionally, recent investigations of 'bet-hedging' strategies in bacteria have explored the contributions of stochasticity and regulation to bacterial phenotypic heterogeneity and examined the effects of these strategies on community survival.

PMID:
25271119
PMCID:
PMC4367450
DOI:
10.1016/j.mib.2014.09.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center