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Curr Opin Chem Biol. 2014 Dec;23:31-8. doi: 10.1016/j.cbpa.2014.09.007. Epub 2014 Sep 29.

Human T cells use CD1 and MR1 to recognize lipids and small molecules.

Author information

1
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.
2
Columbia University, Department of Dermatology, Russ Berrie Medical Science Pavilion, 1150 St Nicholas Avenue, New York, NY 10032, USA.
3
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA. Electronic address: bmoody@partners.org.

Abstract

For decades immunologists thought that T cells solely recognize peptides bound to Major Histocompatibility Complex (MHC) proteins. Therefore, nearly all medical technology that seeks to measure and manipulate human T cells during immunization, infection, allergy and autoimmune diseases relies on peptide antigens. Newer insights into αβ and γδ T cell activation by CD1 or MR1 proteins greatly expand the biochemical range of T cell antigens to include lipids and non-peptidic small molecules. Moving beyond in vitro studies, the recent development of human CD1a, CD1b, CD1c and MR1 tetramers allows direct and specific enumeration of lipid-reactive and small molecule-reactive T cells, providing a new approach to study of T cell-mediated diseases.

PMID:
25271021
DOI:
10.1016/j.cbpa.2014.09.007
[Indexed for MEDLINE]

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