Format

Send to

Choose Destination
Am J Alzheimers Dis Other Demen. 2015 Jun;30(4):412-6. doi: 10.1177/1533317514552667. Epub 2014 Sep 30.

The Chinese Verbal Learning Test specifically assesses hippocampal state.

Author information

1
Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA rtsai@memory.ucsf.edu.
2
Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA.
3
Department of Neurology, Chang Gung Memorial Hospital-Kaoshiung Medical Center and Chang Gung University College of Medicine, Kaoshiung, Taiwan.
4
Department of Neurology, VA Palo Alto Health Care System, Palo Alto, CA, USA.

Abstract

BACKGROUND:

Recently, the Chinese Verbal Learning Test (ChVLT) was developed to assess episodic memory in Chinese speakers. The goal of this analysis was to determine whether memory consolidation as measured by the ChVLT was specifically associated with hippocampal volume in patients with cognitive impairment.

METHODS:

We administered the ChVLT to 22 Chinese-speaking patients with mild cognitive impairment and 9 patients with dementia and obtained hippocampal and cortical volumes from T1-weighted magnetic resonance imaging.

RESULTS:

Linear regression revealed that hippocampal volume explained 9.9% of the variance in delayed memory (P = .018) after controlling for the effects of age, education, immediate recall after the last learning trial, overall level of cognitive impairment, and volumes of other cortical regions.

CONCLUSION:

These results indicate that the ChVLT is specifically correlated with hippocampal volume, supporting its utility for detecting hippocampal disease and monitoring hippocampal state over time.

KEYWORDS:

Alzheimer’s disease; Chinese; hippocampus; memory; mild cognitive impairment

PMID:
25270640
PMCID:
PMC4379122
DOI:
10.1177/1533317514552667
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center