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Int Psychogeriatr. 2015 Mar;27(3):511-25. doi: 10.1017/S1041610214001902. Epub 2014 Sep 30.

Measuring the impact of cognitive and psychosocial interventions in persons with mild cognitive impairment with a randomized single-blind controlled trial: rationale and design of the MEMO+ study.

Author information

Centre de Recherche,Institut Universitaire de Gériatrie de Montréal,Montréal,Québec H3W 1W4,Canada.
McGill Health Center,Montréal,Québec H3G 1A4,Canada.
Faculty of Medicine,McGill University,Montréal,Québec H3G 1Y6,Canada.
Institut Universitaire en santé Mentale de Québec,Québec G1J 2G3,Canada.
Programme de Psychologie,Université Laval,Québec G1V 0A6,Canada.
Programme de Gérontologie,Université de Sherbrooke,Sherbrooke,Québec J1K 2R1,Canada.



Several studies have suggested that cognitive training is a potentially effective way to improve cognition and postpone cognitive decline in older adults with mild cognitive impairment (MCI). The MEMO+ study is a randomized, controlled, single-blind trial designed to test the efficacy, specificity, and long-term effect of a cognitive training intervention and a psychosocial intervention in persons with MCI.


One hundred and sixty-two participants with MCI will be recruited. They will be randomized into three groups: cognitive training, psychosocial intervention, and no-contact. Each intervention will last for eight weeks (one session per week) and a booster training session will be provided three months after the end of the intervention. Various proximal and distal outcomes will be measured at pre-intervention as well as at one week, three months, and six months post-training. Proximal outcomes include memory and psychological health measures. Distal outcomes focus on self-rated functioning in complex daily activities and strategies used in daily life to enhance function. Socio-demographic factors (age, gender, and education), general cognition, personality traits, engagement in activities, and self-efficacy will be used as moderators. Enrolment began in April 2012 and will be completed by December 2014.


This study is likely to have a significant impact on the well-being of persons with MCI by contributing to the development of adapted and scientifically supported cognitive and psychosocial interventions.


neuropsychological testing

[Indexed for MEDLINE]

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