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J Toxicol Environ Health A. 2014;77(21):1281-4. doi: 10.1080/15287394.2014.932313.

Association between prenatal exposure to metals and neonatal morbidity.

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a Department of Environmental Epidemiology , Public Health Services, Ministry of Health , Jerusalem , Israel.


An association between prenatal exposure to (semi-)metals and of neonatal morbidity was assessed by introducing an oxidative stress as a possible intermediate step. An oxidative stress was measured by cell proliferation (CP) ratio in umbilical cord blood cells. Urine samples of 18 out of 58 enrolled women (31%) were positive for (semi-)metals; 25.9% of women were positive for aluminum (Al). The CP ratio was higher (1) in subjects with Al, (2) in mothers to newborns diagnosed as small-for-gestational age (p value = .052), (3) neonates that weighed less (p value = .079), and (4) in women who experienced repeated abortions (p value = .049). Our findings suggest the possibility of metal-induced oxidative stress.

[Indexed for MEDLINE]

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