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Nano Lett. 2014 Oct 8;14(10):5662-71. doi: 10.1021/nl502385k. Epub 2014 Sep 30.

Multifunctional RNA nanoparticles.

Author information

1
Basic Research Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States.

Abstract

Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.

KEYWORDS:

RNA interference; RNA nanoparticles; RNA nanotechnology; RNA−DNA hybrid reassociation; aptamers

PMID:
25267559
PMCID:
PMC4189619
DOI:
10.1021/nl502385k
[Indexed for MEDLINE]
Free PMC Article

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