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EMBO J. 2014 Nov 18;33(22):2601-3. doi: 10.15252/embj.201489988. Epub 2014 Sep 29.

Splicing together sister chromatids.

Author information

1
Centre de Regulació Genòmica, Universitat Pompeu Fabra Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
2
Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Abstract

Splicing of pre‐mRNAs is a necessary step for expression of the majority of genes in higher eukaryotes, and its regulation through alternative splice site selection shapes their proteomes. Defects in multiple splicing factors result in aberrant mitotic progression, although the molecular basis for this observation has remained elusive. Recent papers in The EMBO Journal and EMBO Reports reveal that expression of sororin, a critical regulator that stabilizes cohesin rings in sister chromatids, is exquisitely sensitive to defects in the splicing machinery, thus explaining the striking link between spliceosome function and chromosome segregation.

PMID:
25266476
PMCID:
PMC4282569
DOI:
10.15252/embj.201489988
[Indexed for MEDLINE]
Free PMC Article

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