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Org Biomol Chem. 2014 Nov 21;12(43):8598-602. doi: 10.1039/c4ob01738b.

Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase.

Author information

1
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.

Abstract

Organocatalysts derived from diethylenetriamine effect the rapid isomerization of non-native protein disulfide bonds to native ones. These catalysts contain a pendant hydrophobic moiety to encourage interaction with the non-native state, and two thiol groups with low pKa values that form a disulfide bond with a high E°' value.

PMID:
25266373
PMCID:
PMC4237591
DOI:
10.1039/c4ob01738b
[Indexed for MEDLINE]
Free PMC Article

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