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Ann N Y Acad Sci. 2014 Sep;1325:170-86. doi: 10.1111/nyas.12531.

Translational research on Barrett's esophagus.

Author information

1
Division of Gastroenterology & Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.

Abstract

The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on translational research on Barrett's esophagus that address evidence for genetic instability in esophageal cancer; the role of microsatellite instability; the use of histologic and serum Doublecortin-like kinase 1 expression for progression of Barrett's esophagus to adenocarcinoma; the oxidative stress in Barrett's tumorigenesis; the genomic alterations in esophageal cancer; in vivo modeling in Barrett's esophagus; epigenetic and transcriptional regulation in Barrett's esophagus and esophageal adenocarcinoma; and normal and disordered regeneration in Barrett's esophagus.

KEYWORDS:

Barrett's esophagus; DCLK; OESO; esophageal adenocarcinoma; microsatellite instability; modeling; oxidative stress

PMID:
25266024
DOI:
10.1111/nyas.12531
[Indexed for MEDLINE]

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