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Chem Commun (Camb). 2014 Nov 21;50(90):13896-9. doi: 10.1039/c4cc06200k.

Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage.

Author information

1
Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. liusq@seu.edu.cn.

Abstract

A graphene nano-cage with regulatable space for the assembly of a cytochrome P450 1A2-UDP-glucuronosyltransferase 1A10 bienzyme complex has been constructed via a click reaction, and successfully used to study drug sequential metabolism using an electrochemically-driven method.

PMID:
25264962
DOI:
10.1039/c4cc06200k
[Indexed for MEDLINE]

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