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Life Sci. 2014 Oct 29;116(2):59-66. doi: 10.1016/j.lfs.2014.09.015. Epub 2014 Sep 28.

The heterogenic properties of monocytes/macrophages and neutrophils in inflammatory response in diabetes.

Author information

1
Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, United States.
2
Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States.
3
Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, United States. Electronic address: sun.224@osu.edu.

Abstract

Inflammation is a complicated biological process in response to harmful stimuli, which involves the cooperation of immune system and vascular system. Upon pathogen invasion or tissue injury, resident innate immune cells such as macrophages and dendritic cells are activated and release inflammatory mediators, which result in the vasodilation and recruitment of leukocytes, mainly monocytes and neutrophils. As two of the most important inflammation-mediating immune cells, macrophages and neutrophils have long been regarded to have a pro-inflammatory effect. However, increasing evidences suggest the role of macrophage and neutrophil in inflammation is more complicated and diversified than we thought. Differently activated macrophages and neutrophils lead to diverse even opposite activities. Precise understanding of the role of different subpopulations is critical to achieve the effective treatment for inflammatory diseases. In this review, we discuss the two potentially distinct activation routes of macrophages and neutrophils in obesity and diabetes.

KEYWORDS:

Alternative activation; Classical activation; Inflammation; Macrophage; Neutrophil

PMID:
25264371
PMCID:
PMC4253730
DOI:
10.1016/j.lfs.2014.09.015
[Indexed for MEDLINE]
Free PMC Article

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