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Clin Immunol. 2014 Dec;155(2):209-12. doi: 10.1016/j.clim.2014.09.010. Epub 2014 Sep 28.

Coenzyme Q10 and immunity: A case report and new implications for treatment of recurrent infections in metabolic diseases.

Author information

1
Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA. Electronic address: sfarough@bwh.harvard.edu.
2
Department of Genetics, Brigham and Women's Hospital, Children's Hospital, Boston, MA, USA.
3
Department of Pediatric Neurology, Massachusetts General Hospital, Boston, MA, USA.
4
Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
5
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
6
Pediatric Immunodeficiency Program, Massachusetts General Hospital for Children, Boston, USA. Electronic address: jewalter@mgh.harvard.edu.

Abstract

Coenzyme Q10 (CoQ10) deficiency can manifest diversely, from isolated myopathy to multisystem involvement. Immune dysregulation has not been reported as a feature of the disease. We report a four-year old girl with failure to thrive, recurrent infections, developmental delay with hypotonia, and CoQ10 deficiency with impaired immune function, which improved after CoQ10 and immunoglobulin replacement therapy. Immune dysfunction in CoQ10 deficiency should be considered and treated appropriately.

KEYWORDS:

Coenzyme Q(10;); Immune deficiency; Mitochondria;; Recurrent infections;

PMID:
25264263
DOI:
10.1016/j.clim.2014.09.010
[Indexed for MEDLINE]

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