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Trends Genet. 2014 Dec;30(12):555-64. doi: 10.1016/j.tig.2014.09.002. Epub 2014 Sep 25.

A resourceful genome: updating the functional repertoire and evolutionary role of animal mitochondrial DNAs.

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Département de Sciences Biologiques, Université de Montréal, 90 Avenue Vincent d'Indy, Montréal, Québec H2V 2S9, Canada. Electronic address:
Dipartimento di Scienze Biologiche, Geologiche ed Ambientali, University of Bologna, Via Selmi 3, 40126 Bologna, Italy.
Department of Biology, Acadia University, 24 University Avenue, Wolfville, Nova Scotia B4P 2R6, Canada.


Recent data from mitochondrial genomics and proteomics research demonstrate the existence of several atypical mitochondrial protein-coding genes (other than the standard set of 13) and the involvement of mtDNA-encoded proteins in functions other than energy production in several animal species including humans. These results are of considerable importance for evolutionary and cellular biology because they indicate that animal mtDNAs have a larger functional repertoire than previously believed. This review summarizes recent studies on animal species with a non-standard mitochondrial functional repertoire and discusses how these genetic novelties represent promising candidates for studying the role of the mitochondrial genome in speciation.


ORFan genes; animals; mitochondrial genome; speciation

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