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Neuron. 2014 Oct 22;84(2):470-85. doi: 10.1016/j.neuron.2014.08.051. Epub 2014 Sep 25.

Theta phase segregation of input-specific gamma patterns in entorhinal-hippocampal networks.

Author information

1
New York University Neuroscience Institute and Center for Neural Science, New York University, New York, NY 10016, USA; Department of Physics and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
2
New York University Neuroscience Institute and Center for Neural Science, New York University, New York, NY 10016, USA; School of Physics, Complutense University of Madrid, 28040 Madrid, Spain.
3
New York University Neuroscience Institute and Center for Neural Science, New York University, New York, NY 10016, USA; Allen Institute for Brain Science, Seattle, WA 98103, USA.
4
New York University Neuroscience Institute and Center for Neural Science, New York University, New York, NY 10016, USA; MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary.
5
Department of Physics and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA; Allen Institute for Brain Science, Seattle, WA 98103, USA.
6
New York University Neuroscience Institute and Center for Neural Science, New York University, New York, NY 10016, USA. Electronic address: gyorgy.buzsaki@nyumc.org.

Abstract

Precisely how rhythms support neuronal communication remains obscure. We investigated interregional coordination of gamma oscillations using high-density electrophysiological recordings in the rat hippocampus and entorhinal cortex. We found that 30-80 Hz gamma dominated CA1 local field potentials (LFPs) on the descending phase of CA1 theta waves during navigation, with 60-120 Hz gamma at the theta peak. These signals corresponded to CA3 and entorhinal input, respectively. Above 50 Hz, interregional phase-synchronization of principal cell spikes occurred mostly for LFPs in the axonal target domain. CA1 pyramidal cells were phase-locked mainly to fast gamma (>100 Hz) LFP patterns restricted to CA1, which were strongest at the theta trough. While theta phase coordination of spiking across entorhinal-hippocampal regions depended on memory demands, LFP gamma patterns below 100 Hz in the hippocampus were consistently layer specific and largely reflected afferent activity. Gamma synchronization as a mechanism for interregional communication thus rapidly loses efficacy at higher frequencies.

PMID:
25263753
PMCID:
PMC4253689
DOI:
10.1016/j.neuron.2014.08.051
[Indexed for MEDLINE]
Free PMC Article

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