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Epidemiol Infect. 2015 Jun;143(8):1719-30. doi: 10.1017/S0950268814002489. Epub 2014 Sep 29.

The cost of hospital care for management of invasive group A streptococcal infections in England.

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Field Epidemiology Training Programme,Public Health England,Colindale,London,UK.
Health Protection Directorate,Public Health England,Colindale,London,UK.
Imperial College Faculty of Medicine,Hammersmith Hospital,London,UK.


The objective of this study was to estimate the direct financial costs of hospital care for management of invasive group A streptococcal (GAS) infections using hospital records for cases diagnosed in England. We linked laboratory-confirmed cases (n = 3696) identified through national surveillance to hospital episode statistics and reimbursement codes. From these codes we estimated the direct hospital costs of admissions. Almost all notified invasive GAS cases (92% of 3696) were successfully matched to a primary hospital admission. Of these, secondary admissions (within 30 days of primary admission) were further identified for 593 (17%). After exclusion of nosocomial cases (12%), the median costs of primary and secondary hospital admissions were estimated by subgroup analysis as £1984-£2212 per case, totalling £4·43-£6·34 million per year in England. With adjustment for unmatched cases this equated to £4·84-£6·93 million per year. Adults aged 16-64 years accounted for 48% of costs but only 40% of cases, largely due to an increased number of surgical procedures. The direct costs of hospital admissions for invasive GAS infection are substantial. These estimated costs will contribute to a full assessment of the total economic burden of invasive GAS infection as a means to assess potential savings through prevention measures.


treatment costs

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