Leptomeningeal failure of retinoblastoma

Pediatr Blood Cancer. 2015 Mar;62(3):533-5. doi: 10.1002/pbc.25244. Epub 2014 Sep 27.

Abstract

Leptomeningeal (LM) failure of retinoblastoma (Rb) has not previously been reported. Upon review of our institutional experience of external beam radiotherapy (EBRT) for Rb, we found three LM failures. We sought to better define the clinical parameters of this type of recurrence. All children with LM failure had Reese-Ellsworth stage Vb eyes. Otherwise, no variables were significantly associated with LM failure. We theorize that this phenomenon is a function of the late-stage eyes for which EBRT is being reserved in the modern era.

Keywords: leptomeningeal disease; pediatric malignancy; retinoblastoma.

Publication types

  • Case Reports
  • Clinical Trial

MeSH terms

  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Meningeal Neoplasms / pathology*
  • Meningeal Neoplasms / radiotherapy*
  • Neoplasm Staging
  • Proton Therapy*
  • Retinoblastoma / pathology*
  • Retinoblastoma / radiotherapy*