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Trends Mol Med. 2014 Nov;20(11):623-31. doi: 10.1016/j.molmed.2014.09.002. Epub 2014 Sep 25.

Long non-coding RNAs and control of gene expression in the immune system.

Author information

1
Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
2
Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: kate.fitzgerald@umassmed.edu.

Abstract

All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.

KEYWORDS:

epigenetics; gene expression; innate immunity; lincRNA; lncRNA; long non-coding RNA

PMID:
25262537
PMCID:
PMC4252818
DOI:
10.1016/j.molmed.2014.09.002
[Indexed for MEDLINE]
Free PMC Article

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