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Nat Methods. 2014 Nov;11(11):1138-1140. doi: 10.1038/nmeth.3115. Epub 2014 Sep 28.

Comprehensive analysis of DNA methylation data with RnBeads.

Author information

1
Max Planck Institute for Informatics, Saarbrücken, Germany.
2
Department of Genetics/Epigenetics, Saarland University, Saarbrücken, Germany.
3
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
4
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
#
Contributed equally

Abstract

RnBeads is a software tool for large-scale analysis and interpretation of DNA methylation data, providing a user-friendly analysis workflow that yields detailed hypertext reports (http://rnbeads.mpi-inf.mpg.de/). Supported assays include whole-genome bisulfite sequencing, reduced representation bisulfite sequencing, Infinium microarrays and any other protocol that produces high-resolution DNA methylation data. Notable applications of RnBeads include the analysis of epigenome-wide association studies and epigenetic biomarker discovery in cancer cohorts.

PMID:
25262207
PMCID:
PMC4216143
DOI:
10.1038/nmeth.3115
[Indexed for MEDLINE]
Free PMC Article

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