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Orv Hetil. 2014 Oct 5;155(40):1598-601. doi: 10.1556/OH.2014.30006.

[Attention deficit hyperactivity disorder analyzed with array comparative genome hybridization method. Case report].

[Article in Hungarian; Abstract available in Hungarian from the publisher]

Author information

1
Pécsi Tudományegyetem, Általános Orvostudományi Kar Klinikai Központ, Orvosi Genetikai Intézet Pécs Szigeti út 12. 7624 Pécsi Tudományegyetem Szentágothai János Kutatóközpont Pécs.
2
Pécsi Tudományegyetem, Általános Orvostudományi Kar Klinikai Központ, Orvosi Genetikai Intézet Pécs Szigeti út 12. 7624.

Abstract

in English, Hungarian

One of the most common psychiatric disorders during childhood is attention deficit hyperactivity disorder, which affects 5-6% of children worldwide. Symptoms include attention deficit, hyperactivity, forgetfulness and weak impulse control. The exact mechanism behind the development of the disease is unknown. However, current data suggest that a strong genetic background is responsible, which explains the frequent occurrence within a family. Literature data show that copy number variations are very common in patients with attention deficit hyperactivity disorder. The authors present a patient with attention deficit hyperactivity disorder who proved to have two approximately 400 kb heterozygous microduplications at 6p25.2 and 15q13.3 chromosomal regions detected by comparative genomic hybridization methods. Both duplications affect genes (6p25.2: SLC22A23; 15q13.3: CHRNA7) which may play a role in the development of attention deficit hyperactivity disorder. This case serves as an example of the wide spectrum of indication of the array comparative genome hybridization method.

KEYWORDS:

15q13.3; 6p25.2; ADHD; CHRNA7; SLC22A23; array CGH; attention deficit hyperactivity disorder; duplication; duplikáció; figyelemhiányos hiperaktivitás

PMID:
25261991
DOI:
10.1556/OH.2014.30006
[Indexed for MEDLINE]
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