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Biosens Bioelectron. 2015 Feb 15;64:373-85. doi: 10.1016/j.bios.2014.08.090. Epub 2014 Sep 16.

Recent advances in aptasensors based on graphene and graphene-like nanomaterials.

Author information

1
School of Materials Science & Engineering, College of Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
2
Sorbonne Universités, UPMC, Univ Paris 6, UMR CNRS 7197, Laboratoire de Réactivité de Surface, F-75005 Paris, France; CNRS, UMR 7197, Laboratoire de Réactivité de Surface, F-75005 Paris, France.
3
Department of Biotechnology Engineering, and The Ilse Katz Center for Meso and Nanoscale Science, Faculty of Engineering Sciences, Ben Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel.
4
School of Materials Science & Engineering, College of Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore. Electronic address: wjsteele@ntu.edu.sg.

Abstract

Graphene and graphene-like two-dimensional nanomaterials have aroused tremendous research interest in recent years due to their unique electronic, optical, and mechanical properties associated with their planar structure. Aptamers have exhibited many advantages as molecular recognition elements for sensing devices compared to traditional antibodies. The marriage of two-dimensional nanomaterials and aptamers has emerged many ingenious aptasensing strategies for applications in the fields of clinical diagnosis and food safety. This review highlights current advances in the development and application of two-dimensional nanomaterials-based aptasensors with the focus on two main signal-transducing mechanisms, i.e. electrochemical and optical. A special attention is paid to graphene, a one-atom thick layer of graphite with exceptional properties, representing a fastgrowing field of research. In view of the unique properties of two-dimensional nanostructures and their inherent advantages of synthetic aptamers, we expect that high-performance two-dimensional nanomaterials-based aptasensing devices will find extensive applications in environmental monitoring, biomedical diagnostics, and food safety.

KEYWORDS:

Aptamer; Aptasensor; Biosensor; Graphene; Two-dimensional nanomaterial

PMID:
25261843
DOI:
10.1016/j.bios.2014.08.090
[Indexed for MEDLINE]

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