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Semin Immunopathol. 2014 Nov;36(6):651-8. doi: 10.1007/s00281-014-0443-7. Epub 2014 Sep 27.

Manipulation of host pathways by human cytomegalovirus: insights from genome-wide studies.

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Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel.


The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation. Identifying the pathways that the virus relies on or subverts is of great interest as they have the potential to provide new therapeutic targets and to reveal novel principles in cell biology. Over the past years, high-throughput analyses have profoundly broadened our understanding of the processes that occur during HCMV infection. In this review, we will discuss these new findings and how they impact our understanding of the biology of HCMV.

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