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Neurobiol Aging. 2015 Jan;36(1):547.e1-3. doi: 10.1016/j.neurobiolaging.2014.08.022. Epub 2014 Aug 27.

Population-based analysis of cholesteryl ester transfer protein identifies association between I405V and cognitive decline: the Cache County Study.

Author information

1
Department of Biology, Brigham Young University, Provo, UT, USA.
2
Department of Biology, Brigham Young University, Provo, UT, USA; ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA.
3
Department of Family Consumer and Human Development, Utah State University, Logan, UT, USA; Center for Epidemiologic Studies, Utah State University, Logan, UT, USA.
4
Center for Epidemiologic Studies, Utah State University, Logan, UT, USA; Department of Psychology, Utah State University, Logan, UT, USA.
5
Center for Epidemiologic Studies, Utah State University, Logan, UT, USA; Department of Nutrition, Dietetics, and Food Sciences, Utah State University, Logan, UT, USA.
6
Center for Epidemiologic Studies, Utah State University, Logan, UT, USA; Department of Mathematics and Statistics, Utah State University, Logan, UT, USA.
7
Department of Biology, Brigham Young University, Provo, UT, USA. Electronic address: kauwe@byu.edu.

Abstract

Cholesterol has been implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) and the cholesteryl ester transfer protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer's disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated with cognitive function and LOAD risk, but findings vary and most studies have been conducted using relatively small numbers of samples. To test whether this variant is involved in cognitive function and LOAD progression, we genotyped 4486 subjects with up to 12 years of longitudinal cognitive assessment. Analyses revealed an average 0.6-point decrease per year in the rate of cognitive decline for each additional valine (p < 0.011). We failed to detect the association between CETP I405V and LOAD status (p < 0.28). We conclude that CETP I405V is associated with preserved cognition over time but is not associated with LOAD status.

KEYWORDS:

Alzheimer's; Alzheimer's disease; CETP; Cache county; Cognitive decline; I405V

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