Format

Send to

Choose Destination
Toxicon. 2014 Dec 15;92:36-41. doi: 10.1016/j.toxicon.2014.09.006. Epub 2014 Sep 28.

A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin.

Author information

1
Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, USA.
2
Mapp Biopharmaceutical, Inc., 92121 San Diego, CA, USA.
3
Integrated BioTherapeutics, Gaithersburg, MD, USA.
4
Department of Veterinary Sciences, Iowa State University, USA.
5
University of California, Davis, USA.
6
Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY, USA. Electronic address: nicholas.mantis@health.ny.gov.
7
Mapp Biopharmaceutical, Inc., 92121 San Diego, CA, USA. Electronic address: larry.zeitlin@mappbio.com.

Abstract

Due to the fast-acting nature of ricin, staphylococcal enterotoxin B (SEB), and Clostridium perfringens epsilon toxin (ETX), it is necessary that therapeutic interventions following a bioterrorism incident by one of these toxins occur as soon as possible after intoxication. Moreover, because the clinical manifestations of intoxication by these agents are likely to be indistinguishable from each other, especially following aerosol exposure, we have developed a cocktail of chimeric monoclonal antibodies that is capable of neutralizing all three toxins. The efficacy of this cocktail was demonstrated in mouse models of lethal dose toxin challenge.

KEYWORDS:

Antibody; Biodefense; Therapeutic; Toxin

PMID:
25260254
PMCID:
PMC4248019
DOI:
10.1016/j.toxicon.2014.09.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center