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J Cosmet Laser Ther. 2015 Feb;17(1):20-3. doi: 10.3109/14764172.2014.968577. Epub 2014 Oct 27.

Improvement in skin wrinkles using a preparation containing human growth factors and hyaluronic acid serum.

Author information

1
Nutrex Technology R&D Center , Seoul , South Korea.

Abstract

BACKGROUND:

Skin aging is accompanied by wrinkle formation. At some sites, such as the periorbital skin, this is a relatively early phenomenon.

OBJECTIVE:

We evaluated the anti-wrinkle effect of a preparation containing human growth factor and hyaluronic acid serum on periorbital wrinkles (crow's feet).

MATERIALS AND METHODS:

In total, 23 Korean women (age range: 39-59 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. All the patients completed an 8-week trial of twice-daily application of human growth factor and hyaluronic acid serum on the entire face. Efficacy was based on a global photodamage score, photographs, and image analysis using replicas and visiometer analysis every 4 weeks. The standard wrinkle and roughness parameters used in assessing skin by visiometer were calculated and statistically analyzed.

RESULTS:

Periorbital wrinkles were significantly improved after treatment, with improvements noted both by physician's assessment and visiometer analysis.

CONCLUSION:

Topical application of human growth factor and hyaluronic acid was beneficial in reducing periorbital wrinkles.

KEYWORDS:

human growth factor; hyaluronic acid; wrinkle

PMID:
25260051
DOI:
10.3109/14764172.2014.968577
[Indexed for MEDLINE]

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