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Clin Interv Aging. 2014 Sep 16;9:1563-71. doi: 10.2147/CIA.S67263. eCollection 2014.

The current research status of normal tension glaucoma.

Author information

1
Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China ; Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
2
School of Psychology, Nanjing Normal University, Nanjing, People's Republic of China ; Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
3
Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China ; Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China ; GHM Institute of CNS Regeneration, Jinan University, Guangzhou, People's Republic of China.

Abstract

Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management.

KEYWORDS:

aging; genetics; neurovascular unit; primary open-angle glaucoma; treatment

PMID:
25258525
PMCID:
PMC4172068
DOI:
10.2147/CIA.S67263
[Indexed for MEDLINE]
Free PMC Article

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