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Clin Ophthalmol. 2014 Sep 18;8:1869-75. doi: 10.2147/OPTH.S69804. eCollection 2014.

Differentiation between chalazion and sebaceous carcinoma by noninvasive meibography.

Author information

1
Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan.
2
Itoh Clinic, Saitama, The University of Tokyo, Tokyo, Japan ; Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.
3
Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.

Abstract

BACKGROUND:

Sebaceous carcinoma is notorious for masquerading clinically as other benign lesions such as chalazion. A tool to better differentiate between these two conditions would thus be desirable.

PURPOSE:

To examine the potential application of noninvasive meibography in the differential diagnosis of chalazion and sebaceous carcinoma of the eyelid as a retrospective cross-sectional study.

METHODS:

Five individuals with chalazion and three patients with sebaceous carcinoma were observed. Noninvasive meibography was performed to visualize the reflectivity and shape of the lesion in each subject.

RESULTS:

Noninvasive meibographic imaging revealed chalazion as a lesion of overall low reflectivity with small regions of higher reflectivity corresponding to lipid granules. On the other hand, the noninvasive meibography revealed sebaceous carcinoma as a poorly marginated lesion of high reflectivity in the eyelid.

CONCLUSION:

Noninvasive meibographic imaging may prove useful for the differential diagnosis of chalazion and sebaceous carcinoma. It may also be informative in definition of the resection area in carcinoma patients.

KEYWORDS:

chalazion; eyelid; noninvasive meibography; sebaceous carcinoma

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