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Cell Death Differ. 2015 Mar;22(3):367-76. doi: 10.1038/cdd.2014.143. Epub 2014 Sep 26.

Autosis and autophagic cell death: the dark side of autophagy.

Author information

1
1] Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9113, USA [2] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9113, USA.
2
1] Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9113, USA [2] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9113, USA [3] Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9113, USA [4] Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9113, USA.

Abstract

It is controversial whether cells truly die via autophagy or whether - in dying cells - autophagy is merely an innocent bystander or a well-intentioned 'Good Samaritan' trying to prevent inevitable cellular demise. However, there is increasing evidence that the genetic machinery of autophagy may be essential for cell death in certain settings. We recently identified a novel form of autophagy gene-dependent cell death, termed autosis, which is mediated by the Na(+),K(+)-ATPase pump and has unique morphological features. High levels of cellular autophagy, as occurs with treatment with autophagy-inducing peptides, starvation, or in vivo during certain types of ischemia, can trigger autosis. These findings provide insights into the mechanisms and strategies for prevention of cell death during extreme stress conditions.

PMID:
25257169
PMCID:
PMC4326571
DOI:
10.1038/cdd.2014.143
[Indexed for MEDLINE]
Free PMC Article

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