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Nephron. 1989;51(4):474-7.

Factors influencing the response to hepatitis B vaccination of hemodialysis patients.

Author information

1
Abteilung für Allgemeine Innere Medizin und Nephrologie, Freie Universität, Berlin.

Abstract

The response rate and HBsAG antibody concentrations were examined after hepatitis B vaccination in 78 hemodialysis patients aged between 29 and 79 years. The values were related to age, duration of hemodialysis, body weight, creatinine, urea nitrogen, serum concentrations of beta 2-microglobulin and soluble interleukin-2 receptor (IL-2R). Patients with low anti-HBsAG antibody concentrations (10-100 mU/ml) had significantly higher IL-2R serum concentrations than those with high anti-HBsAG antibody concentrations (greater than 3,000 mU/ml; p less than 0.05). Discriminant multivariate analysis (p = 0.032) revealed the influence (62%) of IL-2R on the response rate while other factors were similar in all patient groups. It is concluded that preactivation of T cells with an increased release of IL-2R may contribute to impaired immune response after hepatitis B vaccination.

PMID:
2525677
DOI:
10.1159/000185379
[Indexed for MEDLINE]

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