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Int J Low Extrem Wounds. 2014 Dec;13(4):273-93. doi: 10.1177/1534734614549416. Epub 2014 Sep 25.

Saving the limb in diabetic patients with ischemic foot lesions complicated by acute infection.

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"Città di Pavia" University and Research Hospital Pavia, Italy
"Città di Pavia" University and Research Hospital Pavia, Italy.


Ischemia and infection are the most important factors affecting the prognosis of foot ulcerations in diabetic patients. To improve the outcome of these patients, it is necessary to aggressively treat 2 important pathologies--namely, occlusive arterial disease affecting the tibial and femoral arteries and infection of the ischemic diabetic foot. Each of these 2 conditions may lead to major limb amputation, and the presence of both critical limb ischemia (CLI) and acute deep infection is a major risk factor for lower-extremity amputation. Thus, the management of diabetic foot ulcers requires specific therapeutic approaches that vary significantly depending on whether foot lesions are complicated by infection and/or ischemia. A multidisciplinary team approach is the key to successful treatment of a diabetic foot ulcer: ischemic diabetic foot ulcers complicated by acute deep infection pose serious treatment challenges because high levels of skill, organization, accuracy, and timing of intervention are required to maximize the chances of limb salvage: these complex issues are better managed by a multidisciplinary clinical group.


acute infection; critical limb ischemia; limb salvage

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