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Mar Drugs. 2014 Sep 24;12(9):4898-911. doi: 10.3390/md12094898.

Anticancer effects of different seaweeds on human colon and breast cancers.

Author information

1
Department of Biological Science, College of Natural Science, Wonkwang University, Iksan, Jeonbuk 570-749, Korea. strozzi37@gmail.com.
2
Department of Biological Science, College of Natural Science, Wonkwang University, Iksan, Jeonbuk 570-749, Korea. velvety7@gmail.com.
3
Department of Food Science and Nutrition, Keimyung University, Daegu 704-701, Korea. obiang@gw.kmu.ac.kr.
4
Department of Biological Science, College of Natural Science, Wonkwang University, Iksan, Jeonbuk 570-749, Korea. cyrabel@hotmail.com.
5
Department of Parasitology and Tropical Medicine, Kyungpook National University, Daegu 700-422, Korea. sylvatriez@yahoo.fr.
6
Department of Biological Science, College of Natural Science, Wonkwang University, Iksan, Jeonbuk 570-749, Korea. dleogns@korea.kr.
7
Department of Civil and Environmental Engineering, Kookmin University, Seoul 136-702, Korea. deliapish@gmail.com.
8
Department of Medicine, College of Medicine, Chung-Ang University, Seoul 156-756, Korea. ksko@cau.ac.kr.
9
College of Pharmacy, Yonsei University, Veritas D, Yonsei International Campus, Songdo-dong, Yeonsu-gu, Incheon 406-840, Korea. kakijane@yonsei.ac.kr.
10
Department of Biological Science, College of Natural Science, Wonkwang University, Iksan, Jeonbuk 570-749, Korea. ykchoo@wku.ac.kr.

Abstract

Seafoods and seaweeds represent some of the most important reservoirs of new therapeutic compounds for humans. Seaweed has been shown to have several biological activities, including anticancer activity. This review focuses on colorectal and breast cancers, which are major causes of cancer-related mortality in men and women. It also describes various compounds extracted from a range of seaweeds that have been shown to eradicate or slow the progression of cancer. Fucoidan extracted from the brown algae Fucus spp. has shown activity against both colorectal and breast cancers. Furthermore, we review the mechanisms through which these compounds can induce apoptosis in vitro and in vivo. By considering the ability of compounds present in seaweeds to act against colorectal and breast cancers, this review highlights the potential use of seaweeds as anticancer agents.

PMID:
25255129
PMCID:
PMC4178489
DOI:
10.3390/md12094898
[Indexed for MEDLINE]
Free PMC Article

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