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Chest. 2015 Jan;147(1):21-4. doi: 10.1378/chest.14-2028.

The association of direct thrombin inhibitor anticoagulants with cardiac thromboses.

Abstract

Direct thrombin inhibitor (anti-factor IIa) anticoagulants, now established for treatment and prevention of cardiac thromboembolism and VTE, have been repeatedly associated with a significantly increased frequency of thrombosis on abnormal cardiac endothelium when compared head-to-head with indirectly acting therapeutic anticoagulants in studies of sufficient patient number and duration. Although there is uncertainty as to the mechanism, the weight of evidence as a class effect warrants prescribing effective anticoagulants other than direct thrombin inhibitors.

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PMID:
25254608
DOI:
10.1378/chest.14-2028
[PubMed - indexed for MEDLINE]
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