Format

Send to

Choose Destination
Faraday Discuss. 2014;169:23-44. doi: 10.1039/c4fd00017j. Epub 2014 Sep 25.

3D molecular models of whole HIV-1 virions generated with cellPACK.

Author information

1
University of California, San Francisco, CA 94143, USA. graham.johnson@ucsf.edu.

Abstract

As knowledge of individual biological processes grows, it becomes increasingly useful to frame new findings within their larger biological contexts in order to generate new systems-scale hypotheses. This report highlights two major iterations of a whole virus model of HIV-1, generated with the cellPACK software. cellPACK integrates structural and systems biology data with packing algorithms to assemble comprehensive 3D models of cell-scale structures in molecular detail. This report describes the biological data, modeling parameters and cellPACK methods used to specify and construct editable models for HIV-1. Anticipating that cellPACK interfaces under development will enable researchers from diverse backgrounds to critique and improve the biological models, we discuss how cellPACK can be used as a framework to unify different types of data across all scales of biology.

PMID:
25253262
PMCID:
PMC4569901
DOI:
10.1039/c4fd00017j
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Royal Society of Chemistry Icon for PubMed Central
Loading ...
Support Center