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Int Braz J Urol. 2014 Jul-Aug;40(4):463-73. doi: 10.1590/S1677-5538.IBJU.2014.04.04.

Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population.

Author information

1
Laboratory of Human Genetics and Laboratory of Functional Genomics and Bioinformatics, Oswaldo Cruz Institute / Oswaldo Cruz Foundation; Laboratory of Applied Genetics, Hematology Service, Rio de Janeiro, RJ, Brazil.
2
Laboratory of Functional Genomics and Bioinformatics, Oswaldo Cruz Institute / Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
3
Laboratory of Human Genetics Oswaldo Cruz Institute / Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil and Brazilian National Institute of Cancer; Laboratory of Human Genetics, Grande Rio University (UNIGRANRIO), Rio de Janeiro, RJ, Brazil.
4
Urology Service of Brazilian National Institute of Cancer, Rio de Janeiro, RJ, Brazil and Mário Kroeff Hospital, Rio de Janeiro, RJ, Brazil.
5
Laboratory of Human Genetics, Oswaldo Cruz Institute / Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
6
Laboratory of Applied Genetics, Hematology Service Brazilian National Institute of Cancer, Rio de Janeiro, RJ, Brazil and Laboratory of Clinical Pathology, Brazilian National Institute of Cancer, Rio de Janeiro, RJ, Brazil.
7
Laboratory of Applied Genetics, Hematology Service Brazilian National Institute of Cancer, Rio de Janeiro, RJ, Brazil.

Abstract

OBJECTIVE:

To evaluate the influence of polymorphisms in GSTA1, GSTM1, GSTT1, and GSTP1 in the risk of developing Prostate Cancer (PCa) in a population of Rio de Janeiro and compare the distribution of allele and genotype frequencies of the polymorphisms analyzed in the present study population with other regions in the country and different ethnic groups.

MATERIALS AND METHODS:

We analyzed a sample of the Brazilian population, comprising 196 patients with PCa treated by the urology services of the Brazilian National Cancer Institute (INCA) and Mario Kroeff Hospital (HMK), and 208 male blood donors from the Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro (UFRJ). The polymorphisms were determined in DNA, extracted from peripheral blood leucocytes using the Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP).

RESULTS:

Our results showed that the distribution of polymorphisms can vary significantly according to the Brazilian region and ethnic groups. The distribution of allele and genotype frequencies of the polymorphism GSTA1 was statistically different between cases and controls. Genotypes (A / B + B / B) were associated with protection (OR = 0.61, 95% CI = 0.40-0.92) for PCa in comparison to genotype A / A.

CONCLUSION:

The distribution of genotype frequencies of the polymorphism GSTA1 was statistically different between the case and control groups (p = 0.023), and the presence of genotypes A / B and B / B suggests a protective role against the risk of PCa compared to genotype A / A. This is the first study that reports the genotypic frequency of this polymorphism and its association with PCa in a Brazilian population sample.

[Indexed for MEDLINE]
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