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Chem Commun (Camb). 2015 Feb 11;51(12):2235-8. doi: 10.1039/c4cc06165a.

The coaction of tonic and phasic dopamine dynamics.

Author information

1
Department of Chemistry and Biochemistry, University of Arizona, 1306 East University Boulevard, Tucson, AZ 85721, USA. mheien@arizona.edu.

Abstract

Tonic neurochemical dopamine activity underlies many brain functions; however a consensus on this important concentration has not yet been reached. In this work, we introduce in vivo fast-scan controlled-adsorption voltammetry to report tonic dopamine concentrations (90 ± 9 nM) and the dopamine diffusion coefficient (1.05 ± 0.09 × 10(-6) cm(2) s(-1)) in the mouse brain.

PMID:
25249291
PMCID:
PMC4825181
DOI:
10.1039/c4cc06165a
[Indexed for MEDLINE]
Free PMC Article

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