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Trends Neurosci. 2014 Oct;37(10):528-30. doi: 10.1016/j.tins.2014.09.001. Epub 2014 Sep 20.

Formation of excitation-inhibition balance: inhibition listens and changes its tune.

Author information

1
Zilkha Neurogenetic Institute, Los Angeles, CA 90089, USA; Department of Cell and Neurobiology, Zilkha Neurogenetic Institute, Los Angeles, CA 90089, USA. Electronic address: htao@usc.edu.
2
Zilkha Neurogenetic Institute, Los Angeles, CA 90089, USA.
3
Zilkha Neurogenetic Institute, Los Angeles, CA 90089, USA; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: liizhang@usc.edu.

Abstract

Recently, Xue, Atallah, and Scanziani reported that excitation/inhibition ratios across cortical pyramidal neurons are equalized by activity-dependent modulations of parvalbumin-neuron mediated feedforward inhibition. Their results raise questions about the developmental formation of this excitation-inhibition balance and the potential activity-dependent synaptic plasticity rules that mediate this process.

PMID:
25248294
PMCID:
PMC4189014
DOI:
10.1016/j.tins.2014.09.001
[Indexed for MEDLINE]
Free PMC Article

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